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Correlations between histopathological and biological findings in nasopharyngeal carcinoma and its prognostic significance
Author(s) -
Gallo Oreste,
Gallina Ezio,
Libonati Giacinto Asprella,
FiniStorchi Omero,
Bianchi Simonetta,
Giannini Augusto
Publication year - 1991
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1288/00005537-199105000-00008
Subject(s) - nasopharyngeal carcinoma , pathology , histiocyte , infiltration (hvac) , cd68 , lymphocytic infiltration , carcinoma , cd20 , immunohistochemistry , biology , medicine , radiation therapy , physics , thermodynamics
Forty‐five consecutive cases of nasopharyngeal carcinoma were morphologically and immunocyto‐chemically studied using monoclonal (anti‐B and anti‐T cell) and polyclonal (anti‐SlOO protein and antilysozyme) antibodies with the peroxidase‐anti‐peroxidase method to identify infiltrating lymphocytes (T and B cell) and histiocytes (monocytic/mac‐rophagic and dendritic cells) in nasopharyngeal carcinoma. A variable density of dendritic cells was found within the tumor nests in 22 (49%) of 45 nasopharyngeal carcinomas examined; infiltrating mac‐rophages were demonstrated in 15 (33%) specimens and around the tumor in almost all cases. Cases with moderate or marked density of dendritic cells (S100 + ) survived longer than those without such infiltration (mean 5‐year survival rates of 31%, 55%, or 64% in patients with absent, moderate, or marked densities, respectively; P<0.05). A significant relationship between monocytic/ macrophagic cells (lysozyme +) within the tumor and survival was also found (mean 5‐year survival rate of 27% or 61% in patients with absent, moderate, or marked densities, respectively). However, lymphocy tic infiltration was not statistically related to a better survival. Analyzing lympho‐cytic infiltration, we found a large prevalence of T cells in the neoplastic tissue without any prognostic significance. These data were correlated to different histo‐logical subtypes according to the principal histologi‐cal classifications of nasopharyngeal carcinomas (Micheau, et al. ; World Health Organization; Cologne University) to individualize the scheme which correlates best with prognosis and biological features of nasopharyngeal carcinomas. Our data suggest that, considering dendritic cells and macrophages within cancer nests, nasopharyngeal carcinoma histiotypes can be correlated to patient prognosis.