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Nasopharyngeal carcinomas and malignant lymphomas: An immunohistochemical analysis of 74 cases
Author(s) -
Sugimoto Takuya,
Hashimoto Hiroshi,
Enjoji Munetomo
Publication year - 1990
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1288/00005537-199007000-00010
Subject(s) - pathology , immunohistochemistry , nasopharyngeal carcinoma , lymphoma , keratin , antigen , carcinoma , large cell , medicine , cell , biology , cancer , adenocarcinoma , immunology , radiation therapy , genetics
Seventy‐four cases of nasopharyngeal malignant neoplasms were analyzed immunohistochemically and classified into 16 lymphomas and 58 carcinomas. Eight lymphomas were of T‐cell origin and eight were of B‐cell origin. Although there were no significant differences in prognoses between patients with carcinoma and those with lymphomn, T‐cell lymphomas resulted in a worse outcome. Five‐year survival rates of T‐cell and B‐cell Iymphoma were 12.5% and 75%, respectively. Polyclonal keratin and tissue polypeptide antigen were more sensitive and specific than other epithelial markers, and were positive in 97% (56 of 58) and 93% (54 of 58) of carcinomas, respectively. With regard to immunophenotypic analysis of malignant lymphomas, L26 to B‐cells (88%) and UCHL1 to T‐cells (100%) led to a satisfactory effect. Immunohistochemical investigations made possible differentiation of malignant lymphomas from a carcinoma and also aided in typing the latter.