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Use of anticytoplasmic autoantibodies in the diagnosis of wegener's granulomatosis with subglottic stenosis
Author(s) -
Gaughan Robert K.,
McDonald Thomas J.,
DeSanto Lawrence W.
Publication year - 1990
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1288/00005537-199006000-00001
Subject(s) - medicine , subglottic stenosis , autoantibody , stenosis , wegener granulomatosis , blood test , diagnostic test , pathology , radiology , dermatology , vasculitis , disease , immunology , antibody , pediatrics
Subglottic stenosis is one of the lesser known manifestations of Wegener's granulomatosis and poses great difficulty in confirming the diagnosis. We present the use of the anticytoplasmic autoantibodies (ACPA) blood test, which has been shown to be highly specific for Wegener's granulomatosis, for corroboration of Wegener's granulomatosis in a patient with subglottic stenosis for whom tissue biopsies were nondiagnostic. The ACPA test and the presentation, diagnosis, and management of subglottic stenosis due to Wegener's granulomatosis are discussed. Otolaryngologists must be aware of the varied manifestations of Wegener's granulomatosis and the availability of the ACPA blood test as an aid in confirming the diagnosis.