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Relation of lymph‐node metastasis to histopathologic appearance in oral cavity and oropharyngeal carcinoma: A case series and literature review
Author(s) -
Rasgon Barry M.,
Cruz Raul M.,
Hilsinger Raymond L.,
Sawicki John E.
Publication year - 1989
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1288/00005537-198911000-00001
Subject(s) - lymph node metastasis , oral cavity , pathology , medicine , carcinoma , lymph node , metastasis , cancer , dentistry
A number of histopathologic parameters in squamous cell carcinoma of the oral cavity and oropharynx have been identified as having a statistically significant correlation with regional lymph‐node metastasis. These parameters have been inconsistent and not readily reproducible. In an attempt to confirm these parameters, a retrospective analysis of 22 patients with Tl to T4 squamous cell carcinoma of the oral cavity and oropharynx was performed. Initially, these patients were managed with either wide local excision or surgical excision of the primary tumor combined with radical neck dissection. There was a minimum of 3 years of follow‐up. Chi‐square contingency tables and Fisher's Exact Test were used to correlate histopathologic parameters with lymph‐node metastasis. Statistically significant correlations were found for tumor thickness and inflammatory infiltrate.