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Experimental replacement of the cervical esophagus in rats with a jejunal free transplantation
Author(s) -
Uchida Léo,
Harii Kiyonori
Publication year - 1989
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1288/00005537-198908000-00011
Subject(s) - anastomosis , transplantation , esophagus , medicine , head and neck , surgery , population , lesion , environmental health
Hypopharynx and cervical‐esophageal reconstruction after malignant‐lesion removal has been a challenging problem for head and neck surgeons. The reconstructive technique has been developed over the years through several ingenious methods of replacement. As a result of recent refinements in microvascular anastomosis techniques, many studies concerning one‐stage, immediate cervical‐esophagus reconstruction have been reported. An experimental study on esophageal reconstruction has been developed using a free intestinal transplantation in two distinct strains of rats. One of the groups consisted of a heterogeneous population of Wistar rats and the other an inbred Lewis strain. In our study the Wistar group reacted as in allograft transplantations and developed an immunological rejection process. The Lewis strain reacted according to isogenic transplantations. The surviving rats were killed and microscopical studies of the reconstructed esophagus were performed. This study is a low‐cost, practical experimental model to achieve a better knowledge of the behavior of the transplanted organs.