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Wound healing: Relationship of wound closing tension to tensile strength in rats
Author(s) -
Morin Garrison,
Burgess Lawrence P.A.,
Rand Michael,
Graeber Geoffrey M.,
Voussoughi Jafar
Publication year - 1989
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1288/00005537-198908000-00003
Subject(s) - ultimate tensile strength , scars , closing (real estate) , tension (geology) , materials science , hairless , tensile strain , wound healing , medicine , biomedical engineering , composite material , surgery , chemistry , biochemistry , political science , law
A study was conducted to better define the relationship between closing tension and the resulting tensile strength of scars in incisional wounds. Five groups consisting of ten hairless rats were studied. Transverse wounds were created and closed on the back of each rat, with closing tension varied by excising amounts of skin in widths of 0 (control), 15, 30, 45, and 60 mm. The tensile strengths were determined at 28 days. Higher mean tensile strengths were demonstrated in the two groups requiring the highest closing tensions (45 mm and 60 mm of skin excision) with P=0.0028 and P=0.00016, respectively. A logarithmic relationship between closing tension and tensile strength was demonstrated using linear regression analysis with t =6.18, p <.0001, and R 2 =.44.