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Multiple steroid receptors in nasopharyngeal angiofibromas
Author(s) -
Brentani M. Mitzi,
Butugan Ossamu,
Paiva Lamartine J.,
Oshima Celina T. F.,
Torloni Humberto
Publication year - 1989
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1288/00005537-198904000-00007
Subject(s) - steroid , receptor , estrogen receptor , glucocorticoid receptor , androgen receptor , progesterone receptor , estrogen , endocrinology , androgen , medicine , chemistry , steroid hormone , biology , hormone , cancer , prostate cancer , breast cancer
Cytosols from 12 nasopharyngeal angiofibroma tissues were analyzed for the presence of estrogen (ER), progesterone (PR), androgen (AR), and glucocorticoid (GR) receptors, by using a dextran charcoal assay. Progesterone receptors (58%) clearly predominate over ER and AR (25%). Thus, nasoangiofibromas can be classified as ER‐PR+ tumors. Glucocorticoid receptors were found in 84% of the tumors. Steroid receptor levels, although slightly higher than those determined in three specimens of normal turbinate, were quantitatively low. Positive PR and AR tumors appeared to correlate with high density of fibroblasts and endothelial cells.