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Induction of HLA‐DR antigen on human squamous carcinoma by recombinant interferon gamma
Author(s) -
Koch Wayne M.,
Richtsmeier William J.,
Diaz Luis A.,
Dugan Elizabeth
Publication year - 1988
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1288/00005537-198805000-00007
Subject(s) - antigen , human leukocyte antigen , immunology , immunotherapy , interferon gamma , major histocompatibility complex , biology , cancer research , cytokine , immune system
The antigen recognition system which plays the major role in immunologic attraction mechanisms, including graft rejection, is the class II major histocompatibility complex containing the HLA‐DR locus. Few types of cells constitutively express this antigen, as it is a potent immunological activating signal usually confined to antigen processing cells, activated lymphocytes, and endothelium. Using indirect immunofluorescence, we have observed induction of the HLA‐ DR glycoprotein in selected head and neck squamous cell carcinoma tissue cultures treated with recombinant interferon gamma. This occurs in concert with growth arrest and morphological changes after rHuIFN‐γ treatment. This report describes the induction of a surface antigen that may have profound prognostic significance. Understanding the kinetics of HLA‐DR induction will aid in the design and assessment of adoptive immunotherapy with rHuIFN‐γ.