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Epithelioid hemangioendothelioma (histiocytoid hemangioma) of the palate
Author(s) -
Moran William J.,
Dobleman Thomas J.,
Bostwick David G.
Publication year - 1987
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1288/00005537-198711000-00009
Subject(s) - epithelioid hemangioendothelioma , hemangioendothelioma , medicine , pathology , differential diagnosis , biopsy , capillary hemangioma , cd34 , hemangioma , vascular tumor , immunohistochemistry , stem cell , biology , genetics
The first case of epithelioid hemangioendothelioma involving the oropharynx is described. A 25‐year‐old woman developed a mass on the palate which was noted to enlarge during the first trimester of pregnancy. Biopsy revealed a cellular tumor initially considered to be of epithelial origin. Vascular differentiation of the tumor was confirmed, however, by positive lectin histochemistry for Ulex europaeus, by evidence of immunoreactivity for factor VIII‐related antigen, and by ultrastructural identification of endothelial features. The patient remains free of tumor 21 months after complete excision. Because of the potential for misdiagnosis, epithelioid hemangioendothelioma should be considered in the differential diagnosis of oropharyngeal malignancies. The effect of pregnancy on the development and growth of vascular tumors such as epithelioid hemangioendothelioma remains uncertain.