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Tracheal reconstruction: In vitro and in vivo animal pilot study
Author(s) -
Wenig Barry L.,
Reuter Victor C.,
Steinberg Bettie M.,
Strong Elliot W.
Publication year - 1987
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1288/00005537-198708000-00014
Subject(s) - limiting , in vivo , tracheal stenosis , animal model , in vitro , stenosis , matrix (chemical analysis) , animal study , pathology , medicine , microbiology and biotechnology , chemistry , biology , surgery , engineering , biochemistry , mechanical engineering , chromatography
In order to further address the problem of tracheal stenosis, an animal model was created to simulate both local and regional tracheal injury. An epithelial equivalent created from a fibroblast‐collagen matrix was used to attempt to either inhibit or lessen the degree of tracheal stenosis that was evident in animal models. Preliminary data appears to show that the epithelial equivalent is effective in limiting and perhaps even abolishing the development of tracheal stenosis.