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Bone resorption in cholesteatoma: Epithelial‐mesenchymal cell interaction and collagenase production
Author(s) -
Moriyama Hiroshi,
Honda Yoshio,
Huang Cheng Chun,
Abramson Maxwell
Publication year - 1987
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1288/00005537-198707000-00016
Subject(s) - cholesteatoma , collagenase , fibroblast , resorption , bone resorption , epithelium , pathology , chemistry , mesenchymal stem cell , wound healing , microbiology and biotechnology , medicine , biology , endocrinology , immunology , surgery , biochemistry , in vitro , enzyme
Abstract Clinical evidence has shown that chronic otitis media with cholestentoma causes greater bone resorption than otitis media without cholesteatoma. What is the role of the epithelium and its products on the morbidity of cholesteatoma? We have studied the mechanism of collagenase production in cultures of rat epidermal cells and skin fibroblast‐like cells under various conditions. The epithelial cells significantly induced mesenchymal cells to produce collagenase. We conclude that interaction between epithelial cells and fibroblast‐like cells enhances production of collagenase. This enhancement of proteolytic activity may be crucial in the series of molecular events resulting in bone resorption associated with cholesteatoma.