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Specific lymphokine responses in cervical nodes of patients with laryngeal cancer
Author(s) -
Cortesina G.,
Beatrice F.,
Morra B.,
Barioglio M. G.,
Poggio E.,
Bussi M.,
Difortunato V.,
Sacchi M.,
Rendine S.,
Sartoris A.
Publication year - 1987
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1288/00005537-198707000-00013
Subject(s) - medicine , lymphokine , peripheral blood mononuclear cell , disease , lymph node , immune system , oncology , pathology , immunology , in vitro , biology , biochemistry
The role of lymphokines in modulating the immune response in patients suffering from neoplastic disease is still controversial. Recent studies indicate that in patients with head and neck cancer, a decrease in LIF (leukocyte migration inhibiting factor) production is usually present in advanced disease. In this study, the authors investigate:1 the LIF production in lymphocytes derived from the peripheral blood and cervical nodes of patients with laryngeal carcinoma by using an autologous pattern ( i.e. , for each patient, the specific LIF production was challenged by means of an autologous cell extract derived from his own tumor); 2 the influence of histologically confirmed cervical node metastases on LIF production.Our results indicate that:1 There is a significant decrease in LIF production in patients with histologically proven cervical node metastases as compared to patients with no metastatic foci. 2 The decrease of LIF production is related to the presence of mononuclear adherent cells. When the latter are removed, there is a significant reversal of specific LIF suppression.The possible meaning of the data is discussed.