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The syndrome of inappropriate secretion of antidiuretic hormone (siadh) following neck dissection
Author(s) -
Wenig Barry L.,
Heller Keith S.
Publication year - 1987
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1288/00005537-198704000-00011
Subject(s) - hyponatremia , antidiuretic , syndrome of inappropriate antidiuretic hormone secretion , medicine , fluid restriction , hormone , neck dissection , dissection (medical) , urinary system , vasopressin , urine osmolality , surgery , endocrinology , cancer
The syndrome of inappropriate secretion of antidiuretic hormone (SIADH) is characterized by hyponatremia and urinary osmolality generally greater than serum osmolality. It is due to inappropriate water retention resulting from excessive release of antidiuretic hormone (ADH). Seventeen patients undergoing neck dissection were studied. Six developed SIADH and two became symptomatic due to profound hyponatremia. Five of the six patients who developed SIADH had previously undergone a neck dissection and/or had received radiation therapy. A suggested pathophysiologic mechanism for this phenomenon is discussed. The syndrome can usually be prevented by fluid restriction during and after surgery.