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Prognostic implications of perineural spread in squamous carcinomas of the head and neck
Author(s) -
Soo KheeChee,
Carter Richard L.,
O'Brien Christopher J.,
Barr Lester,
Bliss Judith M.,
Shaw Henry J.
Publication year - 1986
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1288/00005537-198610000-00015
Subject(s) - perineural invasion , medicine , pharynx , head and neck , larynx , incidence (geometry) , lymph node metastasis , lymph node , head and neck cancer , pathology , surgery , cancer , metastasis , physics , optics
The occurrence and prognostic implications of perineural spread were examined in 239 patients with mucosal squamous carcinomas of the head and neck. Perineural spread was demonstrated in resections from 64 patients (27%), the majority having primary tumors at one of three sites: buccal cavity, larynx, and pharynx. Perineural spread near nodal metastases was uncommon. There was no evidence that perineural involvement was more commonly associated with large tumors or less differentiated ones. No association was established between perineural spread and coexistent lymph node deposits in the surgical resections. Perineural spread was, however, shown to be a statistically significant prognostic factor for an increased incidence of subsequent locoregional recurrence and for decreased survival.