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Extended experimental and preliminary surgical findings with autologous fibrin tissue adhesive made from patient's own blood
Author(s) -
Siedentop Karl H.,
Harris David M.,
Ham Kevin,
Sanchez Ben
Publication year - 1986
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1288/00005537-198610000-00003
Subject(s) - adhesive , fibrinogen , fibrin , fibrin glue , fibrin tissue adhesive , fibrinolysis , biomedical engineering , autologous blood , surgery , medicine , materials science , composite material , layer (electronics) , immunology
A surgical tissue adhesive can be made from the patient's own blood. We have been refining the procedures for manufacturing autologous fibrin tissue adhesive to facilitate its use in the operating room and to increase its bonding strength. Fibrin tissue adhesive efficacy depends on fibrinogen concentration. We found that fibrinogen precipitation using the ammonium sulfate method produced the highest concentration. Bonding power was compared with that of the commercial glue 10 minutes and 30 minutes after glueing two pieces of 1 x 1 cm 2 human dura together. Bonding strength of the autologous product was close to that of the commercial product. Comparisons of fibrinolysis inhibition time of autologous fibrin tissue adhesive and commercial glue in experiments on rats over a period of one hour to six days after subcutaneous injection are described. Preliminary surgical experiences using autologous glue in middle ear surgery are presented.