Premium
Autoimmune thyroiditis: Pathophysiology and relationship to thyroid cancer
Author(s) -
Maceri Dennis R.,
Sullivan Michael J.,
Mcclatchney Kenneth D.
Publication year - 1986
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1288/00005537-198601000-00015
Subject(s) - medicine , thyroiditis , thyroid cancer , malignancy , autoimmune thyroiditis , incidence (geometry) , disease , thyroid , autoimmune disease , population , endocrine system , pathophysiology , cancer , hashimoto disease , immunology , pathology , hormone , physics , environmental health , optics
Autoimmune thyroiditis (Hashimoto's disease) is one of a myriad of clinical entities associated with the endocrine system. The disease is thought to be a defect in the immune regulatory system. The following report is a study of 112 cases of Hashimoto's thyroiditis treated over a 10‐year period. The incidence of malignancy associated with autoimmune thyroiditis in this study was 6.3%, which correlates well with the incidence of thyroid cancer seen in the general population at autopsy. We have concluded from this study that patients with autoimmune thyroid endocrinopathy are at no greater risk for the development of thyroid malignancy than the general population. A review of the pathophysiology of autoimmune disorders is discussed and recommendations for treatment of patients with Hashimoto's disease is provided.