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T‐lymphocytes phenotype and functions in patients with head and neck cancer
Author(s) -
Pierri Ivana,
Cordone Giovanni,
Piccardo Cristina,
Rogna Silvia,
Barabino Andrea,
Indiveri Francesco
Publication year - 1985
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1288/00005537-198505000-00010
Subject(s) - suppressor , mixed lymphocyte reaction , antigen , phenotype , in vitro , immune system , lymphocyte , t lymphocyte , immunology , head and neck cancer , cancer research , cancer , head and neck , cell , t cell , medicine , biology , biochemistry , gene , surgery
We studied the phenotype of T‐lymphocytes isolated from 18 patients with head and neck cancer, their capacity to express Ia antigens upon activation by lectin in vitro , their capacity to function either as responder or stimulator cells in autologous mixed lymphocyte reaction, and thier capacity to cooperate with the normal adherent suppressor cells (NASC). The T‐lymphocytes isolated from these patients have several functional defects including an impaired capacity to activate allogeneic lymphocytes in mixed lymphocyte reactions (MLRs), a lack of a proliferative capacity in autologous MLRs, an impaired sensitivity to inhibition by NASC, and an impaired capacity to express Ia antigens upon activation by mitogens in vitro. These data indicate that, in patients with head and neck cancer, immune function is characterized by a defect in T‐lymphocytes functions which concerns the process of cell to cell cooperation.