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Three‐dimensional computer reconstruction of the neuromuscular junction distribution in the human posterior cricoarytenoid muscle
Author(s) -
Gambino Dean R.,
Malmgren Leslie T.,
Gacek Richard R.
Publication year - 1985
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1288/00005537-198505000-00007
Subject(s) - reinnervation , anatomy , basal lamina , neuromuscular junction , myocyte , neuroscience , synapse , biology , microbiology and biotechnology , ultrastructure
Recent studies have indicated that in a denervated muscle highly specific interactions occur between regenerating axons and the basal lamina of the myofiber precisely at the original synaptic sites. Since these findings suggest that synapse regeneration is facilitated at the original synaptic sites, a knowledge of the distribution of neuromuscular junctions in the human posterior cricoarytenoid (PCA) muscle may guide reinnervation procedures in this muscle. We, therefore, have used histochemical and computer graphics techniques to reconstruct the three‐dimensional distribution of neuromuscular junctions in the human PCA taken fresh at autopsy. The results indicated a more localized pattern of neuromuscular junctions as compared to the human thyroarytenoid muscle. The results will be discussed with respect to their implications for procedures for reinnervation of the posterior cricoarytenoid muscle.