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Immunohistopathology of human olfactory epithelium, nerve and bulb.
Author(s) -
Nakashima Tadashi,
Kimmelman Charles P.,
Snow James B.
Publication year - 1985
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1288/00005537-198504000-00004
Subject(s) - olfactory epithelium , olfactory bulb , olfactory nerve , epithelium , olfactory system , neuroscience , biology , anatomy , central nervous system , genetics
The immunohistochemical characteristics of the human olfactory system were studied using antiserum to the olfactory marker protein (OMP). OMP was detected in the olfactory receptor neurons and processes extending from the olfactory neuroepithelium to the olfactory bulb. The olfactory receptor cells located close to the epithelial surface also contained OMP. In severely degenerate regions, only a few OMP‐containing cells were observed. Differences in OMP‐staining intensity were noted among the olfactory receptor cells in thick neuroepithelium. Proliferating olfactory neuroepithelium contained OMP reactive and nonreactive olfactory receptor cells. The presence of OMP reactive and nonreactive olfactory neurons indicates the coexistence of two functionally different phases of olfactory neurons. These findings suggest that continuous cell turnover is occurring in human olfactory neuroepithelium.