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Safety of 125 iodine and 192 iridium implants to the canine carotid artery: Preliminary report
Author(s) -
Fee Willard E.,
Handen Cynthia,
Goffinet Don R.,
Fajardo Luis F.,
Guthaner Diana
Publication year - 1985
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1288/00005537-198503000-00016
Subject(s) - medicine , carotid arteries , brachytherapy , surgery , nuclear medicine , head and neck , dose rate , dissection (medical) , radiology , radiation therapy , medical physics
Thirty‐nine healthy dogs underwent a simulated radical neck dissection followed by implantation of either 125 Iodine ( 125 I) or 192 Indium ( 192 Ir) in various dose regimes randomized prospcctively from 3,000 to 30,000 rad. Bilateral selective carotid angiography was performed immediately postoperatively and at six months and one year. No significant effects occurred to the animals who received 15,000 rad 125 I or 6,000 rad 192 Ir. In the higher dosed animals the 125 I treated group fared better than the 192 Ir treated group, probably due to the lower dose rate delivery. All surviving animals will be maintained an additional year to determine the late effects of brachytherapy irradiation to the carotid artery.