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Planned preoperative radiation therapy vs. definitive radiotherapy for advanced laryngeal carcinoma
Author(s) -
Kazem Ismail,
Broek Paul Van Den
Publication year - 1984
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1288/00005537-198410000-00017
Subject(s) - medicine , laryngectomy , radiation therapy , neck dissection , carcinoma , surgery , dissection (medical) , larynx
In the period 1970‐1980 inclusive, 191 patients with T 3 T 4 laryngeal carcinoma (glottic.: 63 and supraglottic.: 128) received either definitive radiation therapy (RT) (60‐65 Gy in 6‐7 weeks) or planned preoperative radiation therapy (25 Gy in 5 equal daily fractions of 5 Gy) followed by laryngectomy with or without neck dissection (RT+S). Selection for RT vs. RT+S was based on medical operability and/or patient's refusal to undergo surgery. All patients are evaluable with minimum of 2 years observation. Crude 5 and 10‐year survival probability for 32 patients with glottic localization who received RT is 55% and 38% vs. 65% and 65% respectively for 31 treated with RT+S. For 52 patients with supraglottic site who received RT, the 5 and 10‐year survival is 44% and 44% vs. 82% and 60% for 76 patients treated with RT+S.