Premium
Nonbacterial inflammation as a means of enhancing skin flap survival.
Author(s) -
Liston Stephen L.
Publication year - 1984
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1288/00005537-198408000-00016
Subject(s) - croton oil , microcirculation , inflammation , croton , dorsum , arachidonic acid , metabolite , skin flap , medicine , dermatology , pharmacology , biology , surgery , anatomy , traditional medicine , immunology , biochemistry , enzyme
Painting the skin of the dorsum of a rat with croton oil improved the survival length of caudally based skin flaps. No vasodilation was demonstrated in the deeper layers of skin treated with croton oil. The mechanism by which the application of croton oil leads to improvement of the skin flap survival is thought to be the nonbacterial inflammation produced by the croton oil (a chemical burn). This inflammatory effect probably acts upon the microcirculation via arachidonic acid metabolite mediators.