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Identification of subsets of lymphocytes infiltrating head and neck tumor tissue: A preliminary report
Author(s) -
Rabin Bruce S.,
Johnson Jonas,
Claassen Diana
Publication year - 1984
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1288/00005537-198405000-00022
Subject(s) - infiltration (hvac) , monoclonal antibody , tumor infiltrating lymphocytes , t lymphocyte , head and neck squamous cell carcinoma , lymphocyte subsets , suppressor , pathology , lymphocyte , biology , head and neck , immunology , antibody , t cell , immune system , medicine , head and neck cancer , immunotherapy , gene , cancer , genetics , physics , surgery , thermodynamics
Monoclonal antibodies reactive to distinct subclasses of lymphocytes were used to identify lymphocytes infiltrating tissue obtained from patients with squamous cell carcinoma of the head and neck. The majority of lymphocytes present were T‐cells with very few B‐lymphocytes and natural killer cells present. A variety of patterns of infiltration and relationship of T‐helper to T‐suppressor lymphocytes was noted. Long‐term follow‐up studies will be required to determine the clinical significance of infiltration by different T‐lymphocyte subclasses.