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Mononuclear phagocyte function in head and neck cancer: Depression of murine macrophage accumulation by low molecular weight factors derived from head and neck carcinomas
Author(s) -
Balm Fons J. M.,
Von BlombergVan Deflier B. Mary E.,
Drexhage Hemmo A.,
De HaanMeulman Meeny,
Snow Gordon B.
Publication year - 1984
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1288/00005537-198402000-00016
Subject(s) - medicine , head and neck cancer , infiltration (hvac) , mononuclear phagocyte system , macrophage , peritoneal cavity , head and neck , pathology , intraperitoneal injection , cancer , monocyte , carcinoma , peripheral blood mononuclear cell , surgery , in vitro , biochemistry , physics , thermodynamics , chemistry
In earlier experiments chemotactic responsiveness of peripheral blood monocytes obtained from patients with head and neck cancers was found to be markedly depressed. In an attempt to attribute this defect in migration to an influence excited by low molecular weight factors of less than 25,000 daltons, derived from the tumor, Amicon filtrates of head and neck cancer cells were administered sub‐cutaneously to C3H mice 24 hrs. before the intraperitoneal injection of concanavelin A. Subsequent macrophage accumulation into the peritoneal cavity was quantified. A clear inhibition of macrophage infiltration was found, particularly when filtrates of poorly differentiated tumors were used. Injection of filtrates from healthy oral mucosa were negative, whereas mouse mammary carcinoma filtrates strongly inhibited accumulation.