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Autoradiographic evidence of sex steroid receptors in laryngeal tissues of the baboon (papio cynocephalus)
Author(s) -
Aufdemorte Thomas B.,
Sheridan Peter J.,
Holt G. Richard
Publication year - 1983
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1288/00005537-198312000-00013
Subject(s) - baboon , antiandrogens , testosterone (patch) , receptor , endocrinology , medicine , sex steroid , dihydrotestosterone , larynx , biology , hormone , sex hormone receptor , steroid , androgen , estrogen receptor , anatomy , cancer , antiandrogen , breast cancer
A number of studies have implicated the gonadal steroids as significant factors in laryngeal development and disease. In addition, antiandrogens are receiving limited trials in the treatment of laryngeal carcinoma. However, there is little experimental data to document the presence, and more specifically the location of receptors for the sex steroid hormones in the larynx. The purpose of this study is to provide such data. Utilizing an autoradiographic technique, tissues from baboons injected with tritiated estradiol ( 3 H‐E 2 ) or dihydrotestosterone testosterone ( 3 H‐DHT) were examined and analyzed. The data gathered confirmed that the larynx is rich in receptors for these steroids and that there are specific patterns of distribution of receptor positive cells. The vocalis muscle and other mesenchymal tissues contained the largest number of receptors, while ciliated columnar and stratified squamous epithelium were negative. The significance of these findings is discussed.