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An igd extramedullary plasmacytoma involving the sphenoid sinus at onset: An immunohistochemical study
Author(s) -
Humphrey David M.,
Aufdemorte Thomas B.,
Gates George A.
Publication year - 1983
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1288/00005537-198311000-00016
Subject(s) - medicine , plasmacytoma , pathology , extramedullary plasmacytoma , immunoglobulin d , plasma cell neoplasm , immunohistochemistry , plasma cell , bone marrow , multiple myeloma , antibody , b cell , immunology
A 60‐year‐old man developed a left VIth‐nerve paralysis and underwent biopsy of an extramedullary plasmacytoma in the sphenoid sinus. Immunohistochemistry demonstrated cytoplasmic IgD and lamba determinants. Subsequent specimens from left clavical and thoracic epidural lesions also showed a plasma cell neoplasm with IgD and lamba determinants. No abnormal plasma cells were found in bone marrow specimens. Lambda Bence‐Jones protein and monoclonal IgD‐lambda protein in the serum were detected several months after onset. The patient died with disseminated plasmacytoma 1 year after diagnosis. The mode of presentation, pattern of metastasis, and secretory features were typical of extramedullary plasmacytoma arising in the upper airway. Immunohistochemistry was more productive than serum electrophoresis and immunoelectrophoresis for following the course of this neoplasm.