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Combined preoperative radiotherapy and surgery in the treatment of carcinoma of the anterior two‐thirds of the tongue
Author(s) -
Holm LarsErik,
Lundquist PerGotthard,
Silfverswärd Claes,
Sobin Aron,
Wersäll Jan
Publication year - 1983
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1288/00005537-198306000-00016
Subject(s) - medicine , radiation therapy , tongue , carcinoma , surgery , tongue neoplasm , radiology , pathology
Sixty‐three patients with squamous cell carcinoma of the anterior two‐thirds of the tongue were treated with preoperative external radiotherapy (mean target dose 42.60 Gray or 4260 rad) and surgery. The expected 5‐year survival, expressed as life table estimate of percent of survivors, was 77% for patients with Stage I tumors, 69% with Stage II, and 13% for patients with tumors in Stages III‐IV (p < 0.001). Fourteen patients experienced local recurrences, 7 had homolateral neck metastases, 4 had contralateral neck metastases and 3 had distant metastases. In 15 cases no cancer could be detected at review of the surgical specimens, but 2 of these died of their cancers. In 43 cases cancer was present in the specimens, and 26 of these died of their cancer (p < 0.01).