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Malignant transformation of a nasopharyngeal angiofibroma
Author(s) -
Makek Miro S.,
Andrews James C.,
Fisch Ugo
Publication year - 1989
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1288/00005537-198210000-00021
Subject(s) - angiofibroma , medicine , radiation therapy , malignant transformation , surgical excision , fibrosarcoma , surgery , radiology , pathology
The malignant transformation of a nasopharyngeal angiofibroma is a rare occurrence. This report describes the development of a fibrosarcoma in a patient over a 20‐year period after four surgical procedures and two courses of radiation therapy to control a nasopharyngeal angiofibroma. A review of the literature revealed similar descriptions of this problem. Radiation likely plays a major role in causing the malignant change. An initial complete surgical excision can prevent recurrence of a nasopharyngeal angiofibroma as well as sarcomatous transformation. With the availability of surgical procedures that can completely and safely resect almost all nasopharyngeal angio‐fibromas, radiation therapy can be avoided.