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Beta‐2‐microglobulin as the main component of primary amyloidosis located in the larynx
Author(s) -
ÁnOgazón O. Galv,
Terán L. A.,
Fernandez J.,
Pasquel P.
Publication year - 1989
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1288/00005537-198210000-00018
Subject(s) - amyloidosis , beta 2 microglobulin , amyloid (mycology) , larynx , medicine , immunofluorescence , beta (programming language) , congo red , pathology , stain , serum amyloid p component , amyloid fibril , monoclonal antibody , antibody , staining , immunology , chemistry , anatomy , inflammation , disease , c reactive protein , organic chemistry , adsorption , computer science , programming language , amyloid β
A case of primary amyloidosis located in the larynx in which Beta‐2‐microglobulin (β2m) was the main component of the tissue is presented. Indirect immunofluorescence performed with monoclonal anti‐human β2m antibody (BBM1) showed a positive reaction, as did Congo red stain, and both patterns were similar. A significant increase in serum β2m was observed; however, the clinical condition associated with this elevation remains unclear. We suggest that β2m is not only the main component of secondary amyloidosis in terminal nephropathy patients undergoing hemodialysis for prolonged periods, but that it could be part of the structure of other types of amyloid—either primary or secondary.