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Freeze‐Dried microarterial replacement allografts in rabbits
Author(s) -
Pratty Michael F.,
Bank Harvey L.,
Schmehl Marcia,
Horton William D.
Publication year - 1989
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1288/00005537-198210000-00009
Subject(s) - medicine , surgery , animal model , cryopreservation , head and neck , femoral artery , microvascular surgery , experimental animal , microsurgery , biology , veterinary medicine , embryo , microbiology and biotechnology
Microvascular techniques offer important alternatives for reconstructive head and neck surgery. To test the viability of freeze‐dried allografts, a pilot experimental study was performed using the rabbit model. Freeze‐dried preserved arterial allografts were implanted into femoral artery defects in eight subjects. After 6 weeks, all grafts were harvested and prepared for histologicol and electron microscopic analysis. Immediate patency was 100%. One subject was excluded on the third postoperative day. Of the seven remaining grafts, three (43%) were patent at 6 weeks. These results are comparable to previous data obtained using freeze‐dried arterial allografts in the some animal model. Although further investigation is required, this pilot study suggests possible future application of cryopreserved vascular micrografts.