Premium
Malignant external otitis: Early histopathologic changes and pathogenic mechanism. —MALIGNANT EXTERNAL OTITIS
Author(s) -
Ostfeld Ervin,
Segal Michael,
Czernobilsky Bernard
Publication year - 1981
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1288/00005537-198106000-00015
Subject(s) - otitis , medicine , mechanism (biology) , dermatology , pathology , surgery , physics , quantum mechanics
The histopathologic changes during the early stage of malignant external otitis (MEO) were studied in two patients, one a non‐diabetic. The specimens were obtained by an en bloc excision of the diseased tissue of the external ear canal through a retroauricular approach. The most prominent histologic features of the early stage of MEO consist of a thick layer of almost acellular, partly degenerated, collagen extending from the cartilage into the dermis, which most likely existed prior to the penetration of the microorganism. This finding supports our concept that MEO is a disease which develops as a result of invasion of opportunistic organisms into tissues previously devitalized, probably due to vascular compromise and that these latter features constitute the basic mechanism of the entire disease process.