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Bone destruction due to the rupture of a cholesteatoma sac: A pathogenesis of bone destruction in aural cholesteatoma
Author(s) -
Kaneko Yutaka,
Yuasa Ryo,
Ise Ikuo,
Iino Yukiko,
Shinkawa Hidbichi,
Rokugo Masaaki,
Tomioka Sachiko,
Shibahara Yoshihiro
Publication year - 1980
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1288/00005537-198011000-00015
Subject(s) - cholesteatoma , pathogenesis , medicine , temporal bone , audiology , anatomy , pathology , surgery
Severe bone destruction in a cholesteatoma is one of the characteristic clinical features. To clarify the mechanism of bone destruction in cholesteatoma, the matrix of cholesteatoma and the attached bone, obtained during middle ear surgery, was observed by light microscope. Rupture of the epithelial lining in a cholesteatoma and the escaping contents (keratin), which gave rise to intense characteristic granulations in subepithelial tissue, were found. Furthermore bone destruction was always found at the site of subepithelial tissue of cholesteatoma. From these facts, the escape of contents from the sac of cholesteatoma into the subepithelial layer is considered to be an important factor in the mechanism of bone destruction.