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The use of cromolyn sodium in the prevention of nerve degeneration in bell's palsy
Author(s) -
Mcgovern Francis H.,
Estevez José
Publication year - 1980
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1288/00005537-198010000-00009
Subject(s) - cromolyn sodium , medicine , prednisone , bell's palsy , palsy , mast cell , degranulation , anesthesia , edema , immunology , pathology , asthma , alternative medicine , receptor
Clinical use by inhalation of cromolyn sulphate, a mast cell degranulator inhibitor, within four days after the onset of Bell's palsy will prevent nerve degeneration and provide complete recovery within a range of two weeks. The successful administration of the drug supports our experimental concept of Bell's palsy as an immunological disease. The triggering action of the mast cell as a part of IgE antibody cell mediator system is postulated as the key role on controlling the neural edema. In this paper we contrast the difference in disease duration time and degree of recovery in a group of patients using high dose prednisone therapy and a group using cromolyn sulphate.