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Local IgA‐Class antibodies against respiratory viruses in middle ear and nasopharyngeal secretions of children with secretory otitis media
Author(s) -
Meurman Olli Henrik,
Sarkkinen Hannu Kalevi,
Puhakka Heikki Juhani,
Virolainen Erkki Simo,
Meurman Otto Henrik
Publication year - 1980
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1288/00005537-198002000-00016
Subject(s) - otitis , middle ear , antibody , radioimmunoassay , secretion , titer , virus , virology , antibody titer , immunology , biology , respiratory system , microbiology and biotechnology , medicine , anatomy , genetics
The presence of antibodies against some important respiratory viruses in the middle ear and nasopharyngeal secretions of 52 children with secretory otitis media (SOM) was investigated in order to find out about the role of these viruses in the development of SOM.The method employed was a sensitive radioimmunoassay test. Antibodies to adeno, respiratory syncytial, and parainfluenza 3 viruses were detected in about 50%, 50% and 20% of the patients, respectively. In eight patients the middle ear secretion/nasopharyngeal secretion titer ratio of antibodies to one virus was selectively increased in comparison with the other viruses tested, indicating an active local production of specific antibodies in the middle ear. Further studies are required to determine the cause of such an active antibody synthesis and its possible role in the etiopathogenesis of SOM.