Premium
A double‐blind comparison of oxatomide (R 35 443) and diphenhydramine in the treatment of hay fever
Author(s) -
Van Der Bijl W. J. F.,
Cordier E.,
Van Dishoeck E. A.,
De Proost W.,
Vannieuwenhuyse E.
Publication year - 1980
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1288/00005537-198001000-00015
Subject(s) - diphenhydramine , medicine , hay fever , anesthesia , limiting , double blind , histamine , placebo , mechanical engineering , alternative medicine , pathology , asthma , engineering
Ninety‐one hay fever patients received either 0.5 mg/kg oxatomide b.i.d. or 0.4 mg/kg diphenhydramine b.i.d. in a two‐month double‐blind study. If necessary this dose could be doubled. The results showed that fewer oxatomide patients needed to double this starting dose and to use a nasal spray. Oxatomide proved to be more effective than diphenhydramine in limiting the severity of the hay fever attacks, as evidenced by the findings that oxatomide patients had fewer complaint‐days, and that more of these patients were rated by the investigators to have excellent or good results. Apart from daytime fatigue, transient in several patients, no oxatomide‐induced side‐effects were found.