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Histamine, norepinephrine and serotonin content of nasal polyps
Author(s) -
Bumsted Robert M.,
ElAckad Tarek,
Smith J. Montgomery,
Brody Michael J.
Publication year - 1979
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1288/00005537-197905000-00023
Subject(s) - histamine , nasal polyps , norepinephrine , serotonin , mucous membrane of nose , medicine , edema , endocrinology , pathology , receptor , dopamine
Histamine, norepinephrine and serotonin were assayed and localized by fluorescence histochemistry in normal mucosa and nasal polyps because of their possible role in the development of inflammation and edema. Histamine was present in greater concentration in nasal polyps than in normal mucosa. Norepinephrine was present primarily in the base of nasal polyps and in greater concentration than in normal mucosa. Patients with aspirin sensitivity and asthma had much lower histamine concentrations in their nasal polyps than all other patients with nasal polyps. A proposal for a possible mechanism of formation of nasal polyps based on vascular and inflammatory mechanisms and incorporative roles for histamine and norepinephrine is presented.