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Small cell anaplastic (oat cell) carcinoma of the larynx: Report of a case and review of the literature
Author(s) -
Myerowitz Richard L.,
Barnes E. Leon,
Myers Eugene
Publication year - 1978
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1288/00005537-197810000-00018
Subject(s) - larynx , oat cell carcinoma , radiation therapy , carcinoma , anaplastic carcinoma , medicine , large cell , chemotherapy , pathology , cell , neoplasm , laryngeal neoplasm , lung , cancer , oncology , biology , respiratory disease , surgery , adenocarcinoma , genetics
The fifth reported patient with primary laryngeal oat cell carcinoma is described. Electron microscopy of tumor cells revealed typical neurosecretory‐type granules similar to those described for pulmonary oat cell carcinoma. Analysis of clinical data from all five reported patients revealed that this neoplasm is a virulent one which spreads early and rapidly and kills quickly. Combination chemotherapy and/or radiotherapy, which has significantly prolonged life in patients with oat cell carcinoma of lung, may be indicated as an adjunct to surgery for this rare malignant tumor of the larynx.