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“Smokers' larynx” and carcinoma of the larynx in syrian hamsters exposed to cigarette smoke
Author(s) -
Homburger Freddy
Publication year - 1975
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1288/00005537-197511000-00010
Subject(s) - larynx , smoke , cigarette smoke , medicine , respiratory tract , physiology , cancer , carcinoma , cigarette smoking , laryngeal neoplasm , syrian hamsters , pathology , respiratory system , anatomy , environmental health , hamster , physics , meteorology
Several groups of investigators have recently produced carcinoma of the larynx in Syrian hamsters. This study reports on the effects of cigarette smoke from Kentucky reference cigarettes in an inbred strain (BIO 15.16) of Syrian hamsters. After “smoking” five days each week for two years, 20 percent of the surviving animals had cancer of the larynx; 40 percent had severe epithelial changes. These observations emphasize the role of cigarette smoke in the genesis of laryngeal cancer and respiratory tract cancer in general. An experimental method is now available for comparative studies of cigarettes and as a guide toward less hazardous smoking materials.