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Lathyrogenic effects of vitamin a in the rat embryo
Author(s) -
Yarington C. T.,
Stivers F. Edward
Publication year - 1974
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1288/00005537-197408000-00005
Subject(s) - embryo , vitamin , macroglossia , gestation , hypervitaminosis a , teratology , pregnancy , endocrinology , cartilage , biology , anatomy , retinol , physiology , medicine , tongue , pathology , microbiology and biotechnology , genetics
The effects of large doses of vitamin A during gestation on the embryo rat are described. Cleft palate formation, dose‐related disorganization of mandibular and maxillary growth due to abnormal cartilage deposits, and relative macroglossia are described. The previously described lathyrogenic and teratogenic affects of vitamin A in high doses is confirmed and further study suggested for possible deformities of the developing ear.