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The use of tissue adhesive (isobutyl cyanoacrylate) and topical steroid (0.1 percent dexamethasone) in experimental tympanoplasty
Author(s) -
Kaufman Roger S.
Publication year - 1974
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1288/00005537-197405000-00010
Subject(s) - cyanoacrylate , dexamethasone , tympanoplasty , medicine , middle ear , surgery , corticosteroid , tympanic cavity , adhesive , chemistry , organic chemistry , layer (electronics)
Two main purposes in the present study were: 1. to determine the feasibility of using the tissue adhesive isobutyl 2‐cyanoacrylate in reconstructive middle ear surgery; and 2. to learn whether a potent topical corticosteroid (0.1 percent dexamethasone) would have beneficial anti‐inflammatory effects when placed in the tympanic cavity at the time of middle ear surgery. Tympanoplastic surgery was performed on 26 cat ears and six squirrel monkey ears; the animals were followed for six weeks to nine months postoperatively. The conclusions to be drawn from this experimental study are that presently the tissue adhesive isobutyl cyanoacrylate appears too toxic for use on the delicate middle ear structures; likewise, corticosteroids placed in the middle ear do not appear to have any beneficial effects in tympanoplasty surgery.