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The effect of diazepam on vestibular compensation
Author(s) -
Bernstein Philip,
Mccabe Brian F.,
Ryu Jai H.
Publication year - 1974
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1288/00005537-197402000-00008
Subject(s) - diazepam , vestibular system , cats , medial vestibular nucleus , vestibular nuclei , anesthesia , medicine , compensation (psychology) , audiology , psychology , psychoanalysis
The effect of diazepam (Valium) on vestibular compensation was studied in the cat. Twelve hemilabyrinthectomized cats were given diazepam (0.4 mg/kg/day — physiological dose; 1.6 mg/kg/day — toxic dose) chronically during the compensation period. Thirteen additional hemilabyrinthectomized animals were used as controls. The neural activity of the medial vestibular nucleus was monitored as well as the observations made on nystagmus and postural co‐ordination. The results indicate that diazepam does not delay vestibular compensation in the cat.

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