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Depression of the evoked cortical potential by ethacrynic acid
Author(s) -
Walloch Richard A.,
Anthony Jonathan,
Gibbons Nannette
Publication year - 1974
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1288/00005537-197402000-00007
Subject(s) - evoked potential , microphonics , guinea pig , evoked activity , cortex (anatomy) , electrophysiology , audiology , auditory cortex , depression (economics) , medicine , anesthesia , chemistry , neuroscience , psychology , stimulation , economics , macroeconomics
The effect of a 45 mg/kg injection of Ethacrynic acid upon the threshold of the potential evoked from the guinea pig's auditory cortex was determined. Thirty minutes after the drug injection, the thresholds for the evoked potential at 0.5 and 1 kHz were depressed approximately 20 db, while the thresholds at 4 and 10 kHz were depressed approximately 40 db. Although not complete, substantial recovery of the evoked potential threshold was observed in all but one guinea pig two hours after the drug injection. The changes in the evoked potential threshold were the same order of magnitude as those previously reported for the cochlear microphonic and endolymphatic potential.