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Hypometabolism in allergy: A review for otolaryngologists
Author(s) -
Withers Ben T.
Publication year - 1974
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1288/00005537-197401000-00003
Subject(s) - allergy , atopy , medicine , immunology , hormone , thyroid , mechanism (biology) , philosophy , epistemology
Treatment failure in hyposensitization therapy for allergy is frequently associated with lack of utilizable thyroid hormone in the periphery at the cell level. Basic biochemical principles and endocrinological aspects of the problem relate to the enzymatic mechanism of allergy and atopy (Godlowski). Enzymatic protein synthesis and breakdown in the mitochondria within the cells requires energy supplied by the APT/ADP cycle. In turn, energy from metabolically active thyroid hormone (T 3 ) is necessary as a driving force for the preceding. If T 3 is lacking in the process, faulty, inefficient, toxic enzymes result, which cannot completely break down ragweed or other entering antigens to symptomless metabolites. Toxic allergy symptoms result in the patient. Diagnosis and application of corrective measures in clinical allergy cases as well as treatment precautions will be detailed in representative case reports.