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Prophylactic antibiotics in oral, pharyngeal and laryngeal surgery for cancer: (A double‐blind study)
Author(s) -
Dor Pierre,
Klastersky Jean
Publication year - 1973
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1288/00005537-197312000-00009
Subject(s) - cloxacillin , medicine , placebo , asymptomatic , ampicillin , pharynx , antibiotics , surgery , cancer , anesthesia , pathology , alternative medicine , microbiology and biotechnology , biology
Ampicillin plus Cloxacillin (2 gm of each daily) or a placebo were given at random and on a double blind basis to 52 and 50 patients undergoing oral, laryngeal or pharyngeal surgery for neoplastic lesions. The frequency of postoperative wound and respiratory infections was significantly higher (p <0.05) among the placebo‐treated patients. Most infections in both groups were caused by gram‐negative rods. No untoward effects were related to the use of ampicillin plus cloxacillin and this form of therapy did not increase the rate of pharyngeal or wound asymptomatic colonization by bacteria.