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Gene dosage effect in expression of blood group antigens
Author(s) -
Chen LiTsun,
Davidenas Joseph A.,
Ruth Roal F.
Publication year - 1973
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1288/00005537-197302000-00002
Subject(s) - antigen , gene , blood group antigens , microbiology and biotechnology , antibody , biology , gene expression , immunology , genetics
Chicken blood cells were investigated with respect to the distribution of A blood group antigens on the cell membrane surface via the fluorescent antibody technique. A direct gene‐blood group antigen relationship was found. Erythrocytes from chickens homoqygous for A6 antigen fluoresced more intensely than those from birds heterozygous for the antigen. The respective intensities, approximating a 2:1 ration, idicate a direct gene dosage effect in the expression of at least these antigens. This novel finding disccussed with respect to the possible molecular constitution of and blodd group antigens in other species (e.g., human). This finding has important iplications leading to the understanting of the nature of blood group antigens and the specific role they play in reconstructive surgery.