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Disseminated coccidioidomycosis presenting as facial granulomas in pregnancy: A report of two cases and a review of the literature
Author(s) -
Hadsall Franklin Job,
Acquarelli Mario J.
Publication year - 1973
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1288/00005537-197301000-00005
Subject(s) - medicine , pregnancy , disease , dermatology , presentation (obstetrics) , incidence (geometry) , epiglottis , pathology , pediatrics , surgery , larynx , genetics , physics , optics , biology
The diagnosis of disseminated coccidioidomycosis was made in two pregnant women by the biopsy of facial granulomas. The unusual presentation and the problems associated with the management of this disease in pregnancy stimulated a literature review and a report of these two cases. The history of the discovery and elucidation of this disease is reviewed. Documentation of interhuman transmission of coccidioidomycosis by fomites is presented. Previous reports of disseminated coccidioidomycosis being found in the endolarynx, epiglottis and region of the head and neck are cited. The high incidence of fetal wastage, the high maternal mortality associated with dissemination and the role of Amphotericin B in the therapy of the disseminated disease are discussed.