Open AccessLurasidone-Induced Manic Switch in an Adolescent with Bipolar I Disorder: a Case Report
Author(s) -
Sanjiv Sasidharan Nair,
Chester JieMin Chua,
David Choon Liang Teo
Publication year - 2021
Publication title -
east asian archives of psychiatry : official journal of the hong kong college of psychiatrists = dong ya jing shen ke xue zhi : xianggang jing shen ke yi xue yuan qi kan
Language(s) - English
Resource type - Journals
eISSN - 2224-7041
DOI - 10.12809/eaap2040
Subject(s) - lurasidone , bipolar disorder , medicine , psychiatry , lithium (medication) , schizophrenia (object oriented programming) , antipsychotic
Lurasidone is used for treatment of bipolar depression in adults and adolescents. Lurasidone-associated manic switch has been reported in adults but not yet in adolescents. We report a case of lurasidone-induced manic switch in a male adolescent treated for bipolar I depression. Five days after adding lurasidone to his regimen (sodium valproate and olanzapine), our patient became manic with psychotic features. After discontinuation of lurasidone, he was stabilised with electroconvulsive therapy, and the medication was switched to a lithium-quetiapine combination. This case highlights the potential risk of lurasidone-induced manic switch in adolescents with bipolar depression.