Is metformin effective for reducing weight in obese or overweight adolescents?

YES, TO SOME DEGREE-BUT IT IS OF UNCERTAIN CLINICAL SIGNIFICANCE. OVER A PERIOD OF 6 MONTHS, METFORMIN MODESTLY REDUCED WEIGHT (-2.1 KG) AND BODY FAT MASS (-1.9%), BUT NOT BODY MASS INDEX (BMI) OR LEAN BODY MASS, IN ADOLESCENTS WHO WERE OVERWEIGHT OR OBESE. THIS IS COMPARABLE TO LIFESTYLE INTERVENTIONS (DIET AND EXERCISE) SUPPORTED WITH > 26 HOURS OF COUNSELING, WHICH MODESTLY IMPROVED BMI BUT NOT WEIGHT. (STRENGTH OF RECOMMENDATION [SOR]: A, BASED ON A LARGE META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS [RCTS] OF VARIABLE QUALITY).