Open AccessPrevention, diagnosis and treatment of tumor lysis syndrome
Author(s) -
Michał Piwoński,
Klaudia Żak,
Sylwiusz Niedobylski,
Paweł Stanicki
Publication year - 2021
Publication title -
journal of education, health and sport
Language(s) - English
Resource type - Journals
ISSN - 2391-8306
DOI - 10.12775/jehs.2021.11.09.027
Subject(s) - tumor lysis syndrome , intracellular , uric acid , homeostasis , lysis , extracellular , complication , medicine , phosphate , endocrinology , cancer research , chemistry , biochemistry , chemotherapy , immunology
Tumor lysis syndrome (TLS) is an acute, life-threatening condition that occurs either spontaneously or as a complication of cytoreductive antitumor therapy, and occurs in both children and adults. As a result of TLS, intracellular components are released into the extracellular space, leading to dysregulation of the body's homeostasis due to the accumulation of uric acid, phosphate and potassium ions, and hypocalcemia, which may lead to cardiac arrhythmias, convulsions, or kidney failure.