Open AccessSubstance P blockade effects on peripheral blood leukocytic reaction in secondary chronic inflammation
Author(s) -
Олександр Шевченко,
V. O. Sych
Publication year - 2019
Publication title -
journal of education, health and sport
Language(s) - English
Resource type - Journals
ISSN - 2391-8306
DOI - 10.12775/jehs.2019.09.11.039
Subject(s) - inflammation , blockade , medicine , peripheral blood , substance p , carrageenan , peripheral , immunology , receptor , white blood cell , pharmacology , neuropeptide
In an experimental prospective controlled study the leukocyte response of peripheral blood on the background of blockade of receptors of substance P was studied on the carrageenan model of secondary chronic inflammation in 132 rats. Compared with the natural course of inflammation, at 6 hours there was a significant decrease in total white blood cells count by 1.28 (p<0.05), as well as a significant decrease in the number of polymorphonuclear neutrophils by 4 times (p<0.05) and the number of eosinophils by 3 times (p<0.05) by 10 days. On day 28, there was a significant increase in the number of monocytes in 2 times (p<0,01). The results of the study indicate that in natural conditions of inflammation, substance P stimulates blood leukocytes, as well as prolongs the inflammatory response, and its blocking helps to reduce the inflammatory response.